At USC, Innovation Isn’t Just a Word – It’s Our DNA.

USC Trojan entrepreneurs are fueling the future, one breakthrough at a time.

Who We Are

USC’s Innovation Ecosystem connects and empowers Trojan entrepreneurs, transforming groundbreaking research into real-world solutions.

Facilitated by the Office of Research and Innovation, we provide comprehensive support at every stage of the entrepreneurial journey, driving impact and advancing society.

By The Numbers

#11

USC’s rank in Inc. Magazine’s and Fast Company’s Ignition Schools list of Top 50 academic institutions for entrepreneurship and innovation

#4

Los Angeles’s rank in the 2024 Global Startup Ecosystem Report of the world’s leading startup ecosystems

#15

USC’s ranking of PitchBook’s Universities Top 100 global colleges ranked by startup founders

What We Do

Empowering Innovation at Every Stage

Inspire

Spark your entrepreneurial journey—USC’s early-stage programs ignite ideas, fuel innovation, and turn ambition into action!

Ignite

From spark to startup—Office of Research and Innovation’s seed funding and internal support programs help early-stage ventures gain traction and thrive.

Invest

Big ideas deserve bold backing—USC strategically invests in its entrepreneurs to accelerate startup success.

Innovation Allies: Our Team

USC’s innovation ecosystem is powered by internal and external partners dedicated to Trojan entrepreneurs. Meet the allies who help turn groundbreaking ideas into real-world impact.

Innovation Core

Office of Research Initiatives and Infrastructure

Learn more at rii.usc.edu

Office of Research Strategy and Development

Learn more at rsd.usc.edu

USC Stevens Center for Innovation

Learn more at stevens.usc.edu

USC Alfred E. Mann Institute

Email us at twarsi@usc.edu

Foundational Partner

Digital Economy Program

USC + Techstars Partnership

Campus Partners

Innovation Quest

USC Marshall School of Business

Lloyd Greif Center for Entrepreneurial Studies

USC Viterbi School of Engineering

Technology Innovation & Entrepreneurship

USC Viterbi School of Engineering

I-Corps Hub:
West Region

Keck School of Medicine of USC

MESH Strategic Partnerships

News & Events: The Pulse of Innovation

Latest News

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  • USC and Techstars Digital Economy Program – Accelerator Launch + Start-Up Weekend
    by Jordan Locy on April 29, 2025 at 8:55 pm

    Author: Ethan Bochicchio USC-Techstars Program Updates This April 11 marks the beginning of Start-Up Week for the USC and Techstars Digital Economy Program. Open to USC faculty, staff, students, and alumni, aspiring entrepreneurs will have the opportunity to attend an immersive event where they will have the opportunity to learn from experts, expand their network,…

  • OORI & USC Stevens Supported USC Research Startup is Listed on the Nasdaq
    by Jordan Locy on April 9, 2025 at 9:16 pm

    Author: Ethan Bochicchio On March 26, USC-licensed startup NeOnc Technologies Holdings Inc., having developed an intranasal drug delivery system for brain tumors, was listed for the first time on the Nasdaq. Based on intellectual property developed by USC Keck Medicine’s Dr. Thomas Chen, founder of NeOnc, the company is the first USC-licensed biotech company with…

  • Six USC Faculty Members Elected to National Academy of Inventors (NAI) Senior Member Program
    by Jordan Locy on March 19, 2025 at 8:58 pm

    In a testament to the University of Southern California’s (USC) commitment to innovation and research excellence, six distinguished faculty members have been elected as Senior Members of the National Academy of Inventors (NAI) for the 2025 nomination cycle. This prestigious recognition underscores their significant contributions to their respective fields and highlights USC’s supportive environment for…

  • USC Team Receives $500,000 from NEH for “LA2026” Project
    by Jordan Locy on January 15, 2025 at 7:34 pm

    The University of Southern California’s (USC) Office of Research and Innovation (OORI) is thrilled to announce the recent award made by the National Endowment of the Humanities (NEH) to Dr. Peter Mancall and the USC-Huntington Early Modern Studies Institute (EMSI) based at USC Dornsife College of Letters, Arts, and Sciences. Dr. Peter Mancall previously received…

  • USC-Techstars Inaugural University Catalyst Program Commences
    by Jordan Locy on January 15, 2025 at 7:33 pm

    The University of Southern California (USC) and Techstars Digital Economy Program’s inaugural University Catalyst program commenced at the close of 2024, following a successful 10-week program that ran from September through November. The USC and Techstars University Catalyst Program is a collaborative initiative between the University of Southern California (USC) and Techstars, aimed at fostering…

Upcoming Events

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Success Stories: Trojan Entrepreneurs in Motion